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BIOLOGICAL CELL MEMBRANE DYNAMICS INDUCED BY ELECTRIC PULSES- Background, Experiment and Modeling [Paperback]

By Zhen Ji
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Item description for BIOLOGICAL CELL MEMBRANE DYNAMICS INDUCED BY ELECTRIC PULSES- Background, Experiment and Modeling by Zhen Ji...

Electroporation has been found to be a very effective approach to introduce low and high molecular weight molecules such as drugs, hormones, proteins, DNA, and chromosomes into biological cells. Although electroporation has been under investigation for long time, the dynamic formation and resealing of pores is still not completely understood. In this work, we first computationally analyzed the electric field dosimetry for a Gigahertz Transverse Electromagnetic chamber. We found that this exposure method suffered from undesirable field polarity oscillations. Using a novel micro-fabricated microcuvette and pulse delivering system, we conducted a series of experimental studies of electroporation of HL-60 cells. Theoretical models were also employed to describe the mechanisms for pore formation and development of a spherical (HL-60) cell. A locally constrained surface tension model was proposed to represent the cytoskeleton and anchor proteins in the cell membrane and was observed to provide a plausible explanation for experimental evidence of long-lived pores. Also, transport mechanisms of small charged molecules associated with electroporation were analyzed.



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Item Specifications...


Pages   152
Est. Packaging Dimensions:   Length: 9.61" Width: 6.69" Height: 0.33"
Weight:   0.56 lbs.
Binding  Softcover
Release Date   Dec 20, 2007
Publisher   VDM Verlag Dr. Mueller e.K.
ISBN  3836455366  
ISBN13  9783836455367  


Availability  110 units.
Availability accurate as of Mar 28, 2017 03:58.
Usually ships within one to two business days from La Vergne, TN.
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Product Categories

1Books > Subjects > Professional & Technical > Professional Science > Biological Sciences > Biology > Biology
2Books > Subjects > Science > Biological Sciences > Biology > General
3Books > Subjects > Science > General



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