Item description for Aromatase Inhibitors (Milestones in Drug Therapy) (Milestones in Drug Therapy) by William R. Miller...
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hencethe enzyme'strivial name,aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However,second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest thatthese agents will become the cornerstones of future endocrine therapy.
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Est. Packaging Dimensions: Length: 9.2" Width: 6.5" Height: 0.7" Weight: 1.2 lbs.
Release Date Dec 22, 2005
ISBN 3764371994 ISBN13 9783764371999
Availability 0 units.
More About William R. Miller
The late William M. Murray was Professor Emeritus at Massachusetts Institute of Technology. Dr. Murray was the founder and President of the International Society for Experimental Mechanics. William R. Miller is Professor Emeritus at the University of Toledo. He has taught in the area of mechanical design and its allied subjects, and has served as a consultant to a number of companies.