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Ligand Binding in the Transmembrane Region of Metabotropic Glutamate Receptors [Paperback]

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Item description for Ligand Binding in the Transmembrane Region of Metabotropic Glutamate Receptors by Tobias Noeske...

Group I metabotropic glutamate receptors (mGluRs) play an important role in the treatment of numerous neurodegenerative, cognitive and psychiatric disorders. How can we identify exogenous ligands mediating the effects of mGluRs? How do these ligands affect the receptor? The author Tobias Noeske presents the establishment of strategies for the identification and optimization of molecules acting as non-competitive antagonists of group I mGluRs. These strategies ensure high diversity in the identified chemotypes not resembling original reference molecules ("scaffold-hopping"). The detection of new scaffolds, in turn, is divided into two approaches: First the development of pharmacological assays to screen compounds at a certain target for their bioactivity, and second the evaluation of computer aided methods for the identification of virtual hits to be screened on the pharmacological assays. Promising molecules were optimized regarding bioactivity and selectivity, their binding mode investigated and, finally, compared to existing lead compounds. This book addresses scientists in academia and industry working in early stage drug discovery, predominantly in computer aided drug design.

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Item Specifications...

Pages   204
Est. Packaging Dimensions:   Length: 9.61" Width: 6.69" Height: 0.43"
Weight:   0.73 lbs.
Binding  Softcover
Release Date   Aug 10, 2007
Publisher   VDM Verlag Dr. Mueller e.K.
ISBN  3836423375  
ISBN13  9783836423373  

Availability  61 units.
Availability accurate as of May 28, 2017 04:29.
Usually ships within one to two business days from La Vergne, TN.
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1Books > Subjects > Medicine > Basic Science > Genetics
2Books > Subjects > Medicine > General
3Books > Subjects > Medicine > Specialties > Pathology > Laboratory Medicine
4Books > Subjects > Professional & Technical > Medical > Basic Sciences > Genetics
5Books > Subjects > Professional & Technical > Medical > Medicine > Internal Medicine > Pathology > Laboratory Medicine

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