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Human Immunodeficiency Viruses and Human T-Cell Lymphotropic Viruses (IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans) Volume 67 [Paperback]

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Item description for Human Immunodeficiency Viruses and Human T-Cell Lymphotropic Viruses (IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans) Volume 67 by The International Agency for Research on Cancer...

Evaluates the carcinogenic risk to humans posed by infections with human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2) and human T-cell lymphotropic viruses types I and II (HTLV-I and HTLV-II). Although emphasis is placed on carcinogenicity assessment, the monographs also provide richly detailed descriptions of the viruses' genetic and structural features, methods of detection, routes of transmission, geographical distribution of infection, clinical manifestations of non-neoplastic disorders, and currently available methods of treatment and prevention. For HIV infection, the evaluation of studies of cancer in humans considers abundant evidence, from case reports and epidemiological studies, pointing to greatly increased incidences of Kaposi's sarcoma and non-Hodgkin's lymphoma in persons infected with HIV-1. Data suggesting an association between HIV infection and cervical, anal, and several other cancers are also carefully assessed. Other data considered include findings from animal studies and investigations of the mechanisms by which immune dysfunction may contribute to the genesis of cancer. On the basis of this evaluation, the monograph concludes that infection with HIV-1 is carcinogenic to humans. Infection with HIV-2 was classified as possibly carcinogenic to humans. The second monograph provides a similarly detailed evaluation of human T-cell lymphotropic viruses, which are the only known human oncornavirinae. Concerning studies of cancer in humans, particular attention is given to evidence of an association between HTLV-I and adult T-cell leukemia/lymphoma, which occurs almost exclusively in areas where this infection is endemic. In addition, several case-control studies have found an association between HTLV-I seroprevalence and tumors of the vagina, cervix and liver, but confounding effects and bias could not be excluded. The evaluation also considered findings from animal carcinogenicity studies and from investigations of the molecular mechanisms of leukemogenesis. On the basis of this evaluation, the monograph concludes that HTLV-I is carcinogenic to humans. HTLV-II could not be classified as to its carcinogenicity to humans.



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Item Specifications...


Studio: World Health Organization
Pages   424
Est. Packaging Dimensions:   Length: 10" Width: 7" Height: 0.91"
Weight:   1.7 lbs.
Binding  Softcover
Publisher   World Health Organisation
ISBN  9283212673  
ISBN13  9789283212676  


Availability  82 units.
Availability accurate as of May 30, 2017 07:39.
Usually ships within one to two business days from La Vergne, TN.
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More About The International Agency for Research on Cancer


Register your artisan biography and upload your photo! The International Agency for Research on Cancer (IARC) is part of the World Health Organization. IARC's mission is to coordinate and conduct research on the causes of human cancer, the mechanisms of carcinogenesis, and to develop scientific strategies for cancer control. The Agency is involved in both epidemiological and laboratory research and disseminates scientific information through publications, meetings, courses, and fellowships.

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1Books > Subjects > Health, Mind & Body > General
2Books > Subjects > Health, Mind & Body
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11Books > Subjects > Professional & Technical > Medical > Medicine > Internal Medicine > Oncology
12Books > Subjects > Professional & Technical > Medical > Research



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