Item description for The Hereditary Basis of Allergic Diseases (Progress in Inflammation Research) by Stephen T. Holgate...
Allergic diseases are complex and involve a range of environmental factors interacting with a susceptible genotype. The familial clustering of diseases, such as asthma and hay fever, has been recognised for over two centuries, but identification of the genetic basis to this had to await the molecular biological revolution. Estimates of the contribution that genetic factors make to asthma susceptibility range from 35% to 70%. For the majority of allergic diseases, segregation analysis has not identified a consistent Mendelian pattern of inheritance, which, when combined with multiple phenotypes and environmental interactions, has made identifying candidate genes especially difficult and, at times, controversial. Part of the difficulty has been lack of agreement over phenotype definitions, reduced power of studies to predict linkage and association, and, importantly, lack of true heterogeneity between populations. Despite these difficulties, the last decade has witnessed enormous progress in this field.
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Est. Packaging Dimensions: Length: 9.1" Width: 6.4" Height: 0.6" Weight: 1.35 lbs.
Release Date Sep 17, 2002
Publisher Birkhäuser Basel
ISBN 3764364025 ISBN13 9783764364021
Availability 92 units. Availability accurate as of Mar 26, 2017 03:32.
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More About Stephen T. Holgate
STEPHEN T. HOLGATE, MD, DSc, FRCP, is Medical Research Council Professor of Immunopharmacology and Honorary Consultant Physician at Southampton University Hospital Trust. He is the Chairman of Science Council s Science in Health Group, as well as a member of Royal Commission on Environmental Pollution. His research works have focused on cellular and mediator mechanisms of allergy and asthma, with specific emphasis on applications to diagnosis and treatment. S. T. Holgate is the Co-editor of "Clinical and Experimental Allergy", in addition to being on the editorial board of over 25 journals. He has published over 800 peer-reviewed papers besides editing more than 50 books on asthma.
Stephen T. Holgate currently resides in Southhampton. Stephen T. Holgate has an academic affiliation as follows - Clinical Professor of Immunopharmacology, Southampton General Hospital.