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Polymeric Micelle Nanocarriers for the Treatment of Disseminated Candidiasis [Paperback]

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Item description for Polymeric Micelle Nanocarriers for the Treatment of Disseminated Candidiasis by Ronak Vakil...

The potential of polymeric micelles formed from biocompatible or generally regarded as safe (GRAS) materials as sustained release nanocarriers for amphotericin B has been evaluated in this dissertation as further development can proceed without an explicit concern for biocompatibility which may slow progress of particulate carriers prepared from novel synthetic polymers. PEG-phospholipid (PEG-DSPE) micelles clearly prevented AmB induced toxicity pointing to stable drug incorporation, in vitro. However, drug release and absorption kinetics revealed that AmB was rapidly dissociated from PEG-DSPE micelles in serum albumin, a likely situation in vivo. Cholesterol co-incorporation influenced properties of PEG-DSPE micelles and slowed AmB release in serum albumin raising promise as long circulating carriers for AmB delivery. Further, AmB in PEG-DSPE micelles was stable in saline when combined with 5-fluorocytosine and solubilized rapamycin. Hence, PEG-DSPE micelles represent an interesting alternative to deoxycholate-AmB, particularly in combination therapy involving AmB with optional continuous infusion or sodium supplementation.

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Item Specifications...

Pages   164
Est. Packaging Dimensions:   Length: 9.61" Width: 6.69" Height: 0.35"
Weight:   0.6 lbs.
Binding  Softcover
Release Date   Feb 11, 2008
Publisher   VDM Verlag Dr. Mueller e.K.
ISBN  3836460807  
ISBN13  9783836460804  

Availability  122 units.
Availability accurate as of May 29, 2017 01:37.
Usually ships within one to two business days from La Vergne, TN.
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Product Categories

1Books > Subjects > Medicine > General
2Books > Subjects > Medicine > Pharmacology > Pharmacy
3Books > Subjects > Professional & Technical > Medical > Pharmacology > Pharmacy

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