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Mif: Most Interesting Factor [Hardcover]

By Richard Bucala (Author)
Our Price $ 65.80  
Retail Value $ 94.00  
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Item Number 164966  
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Item description for Mif: Most Interesting Factor by Richard Bucala...

In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF s molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-expression alleles have been associated with rheumatoid arthritis, asthma severity, sarcoidosis, atopy, inflammatory bowel disease, and other inflammatory and infectious maladies. The book also discusses the role of MIF as a therapeutic target. Unique structural features of the protein, such as an intrinsic catalytic activity and the recent discovery of its cell surface receptor, offer attractive opportunities for therapeutic intervention. Such approaches are presently in clinical development.

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Item Specifications...

Studio: World Scientific Publishing Company
Pages   332
Est. Packaging Dimensions:   Length: 8.98" Width: 6.06" Height: 0.79"
Weight:   1.41 lbs.
Binding  Hardcover
Release Date   Jul 27, 2007
Publisher   World Scientific Publishing Company
ISBN  9812706488  
ISBN13  9789812706485  

Availability  0 units.

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Product Categories

1Books > Subjects > Medicine > Basic Science > Immunology
2Books > Subjects > Medicine > Basic Science > Physiology
3Books > Subjects > Medicine > General
4Books > Subjects > Medicine > Specialties > Pathology > General
5Books > Subjects > Medicine > Specialties > Pathology
6Books > Subjects > Professional & Technical > Medical > Basic Sciences > Physiology
7Books > Subjects > Professional & Technical > Medical > Medicine > Internal Medicine > Pathology > General
8Books > Subjects > Professional & Technical > Professional Science > Biological Sciences > Biology > Cytology
9Books > Subjects > Science > Biological Sciences > Biology > Cell Biology
10Books > Subjects > Science > Biological Sciences > Biology > General

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