Item description for Phylogenetic Analysis of Viral Quasispecies by Patricia Buendia...
A new approach in the analysis of viral evolution is presented in this book, an approach that merges Phylogenetic analysis and Bioinformatic techniques. Patterns of viral evolution are inferred from serially-sampled sequence data, i.e., sequence data obtained from strains isolated at consecutive time points from a single patient or host. Traditional phylogenetic methods assume a tree-like evolutionary model, while many RNA viruses have the capacity to exchange genetic material with one another using a process called recombination. A genealogy involving recombination is best described by a network structure. A more general approach was implemented in a new computational tool, Sliding MinPD, one that is mindful of the sampling times of the input sequences and that reconstructs the viral evolutionary relationships in the form of a network structure with implicit representations of recombination events. The underlying network organization reveals unique patterns of viral evolution and could help explain the emergence of disease-associated mutants and drug-resistant strains, with implications for patient prognosis and treatment strategies.
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Est. Packaging Dimensions: Length: 9.61" Width: 6.69" Height: 0.45" Weight: 0.76 lbs.
Release Date Jan 7, 2008
Publisher VDM Verlag Dr. Mueller e.K.
ISBN 383643458X ISBN13 9783836434584
Availability 92 units. Availability accurate as of May 27, 2017 02:34.
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