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Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology) [Hardcover]

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Item description for Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology) by Michael B.A. Oldstone...

The conceptual basis for molecular mimicry was first defined in the early 1980s when monoclonal antibodies against viruses were also shown to react with non-viral host protein; in this case, measles virus phosphoprotein cross-reacted with host cell cytokeratin, herpes simplex virus type 1 with host-cell vimentinand vaccinia virus with host-cell intermediate filaments. Following this discovery, others emerged, again at the clonal level, that T cell clones against proteins from a variety of infectious agents also reacted with host antigenic determinants. The clonal distinction was imperative for the initial definition of mimicry. At least 30 years prior to our initial description of molecular mimicry involving cross-reactions between numerous microbes, on the polyclonal antibody level, streptococcus was believed to react with renal glomeruli, heart and basal ganglia to account for the glomerulonephritis, heart and valvular disease and chorea, respectively. However, subsequent research showed that the nephritis was caused by immune complex deposits and the tissue damage they produced. Later, in 1990, the cross-reactivity of streptococcal antigen with myocardial antigens on a clonal level was uncovered. Hence, for both historical reasons and mechanistic understanding, it is best to provide evidence for cross-reactivity at the clonal level to prove that molecular mimicry exists.





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Item Specifications...


Pages   168
Est. Packaging Dimensions:   Length: 9.3" Width: 6.2" Height: 0.5"
Weight:   0.8 lbs.
Binding  Hardcover
Release Date   Dec 19, 2005
Publisher   Springer
ISBN  3540255974  
ISBN13  9783540255970  


Availability  102 units.
Availability accurate as of Mar 27, 2017 12:46.
Usually ships within one to two business days from La Vergne, TN.
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