Item description for Mechanical Forces and the Endothelium (Endothelial Cell Research Series) by Michael A Gimbrone Jr. & Peter Lelkes...
Although systematic experimentation to elucidate the mechanisms of biomechanical activation of the endothelium has only a short history, impressive strides have been made in elucidating the cellular and molecular events involved. Initial multidisciplinary work provided an impressive descriptive fund of knowledge about the overall response of the endothelium to hemodynamic forces, and molecular biology has provided the tools for the discovery process to take a quantum leap forward in recent years. Thus the level of analysis has moved from secreted protein product to cytoplasmic mRNA content and then to genetic regulatory events within the nucleus. Each of these areas is addressed in detail in this volume, with gene regulation taking a central role. Also considered are fluid mechanics and transduction of mechanical signals, a complex area given the variety of biomechanical stimuli to which the vasculature may be exposed. Our understanding of vascular development and differentiation should be aug
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Studio: Informa Healthcare
Est. Packaging Dimensions: Length: 9.98" Width: 6.88" Height: 1.08" Weight: 2.26 lbs.
Release Date Aug 1, 1999
ISBN 9057024470 ISBN13 9789057024474