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Tissue Engineered Scaffolds for Nerve Regeneration: Gradients of Molecules Enhance Nerve Regeneration [Paperback]

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Item description for Tissue Engineered Scaffolds for Nerve Regeneration: Gradients of Molecules Enhance Nerve Regeneration by Mahesh Dodla...

Injuries to the nervous system result in severe loss of motor and sensory functions. Nerve autografts are widely used clinically to repair injured nerves. However, nerve grafts have many limitations, including availability and loss of function at donor site. To overcome these problems, we have used a tissue engineering approach to design three-dimensional (3D) scaffolds containing laminin-1 (LN-1) and nerve growth factor (NGF). After nerve injury and during embryonic development, several extra-cellular matrix molecules and neurotrophic factors contribute to nerve regeneration and repair. Our 3D agarose hydrogel scaffolds with gradients of LN-1 and NGF are designed to mimic these in vivo conditions to promote nerve regeneration in rats. These scaffolds have shown to promote nerve regeneration comparable to using nerve autografts in rats. This book, therefore, provides a novel technique of nerve scaffold preparation for greater success in nerve regeneration. Scientists and students of neural engineering could use this technique to design novel scaffolds. Optimization of this technique could result in a viable alternative to using nerve grafts for nerve regeneration.



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Item Specifications...


Pages   164
Est. Packaging Dimensions:   Length: 9.44" Width: 6.69" Height: 0.4"
Weight:   0.76 lbs.
Binding  Softcover
Release Date   Feb 27, 2008
Publisher   VDM Verlag
ISBN  3836457636  
ISBN13  9783836457637  


Availability  121 units.
Availability accurate as of Jan 17, 2017 08:39.
Usually ships within one to two business days from La Vergne, TN.
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Product Categories

1Books > Subjects > Medicine > Special Topics > Biotechnology
2Books > Subjects > Professional & Technical > Engineering > Bioengineering > Biomedical Engineering
3Books > Subjects > Professional & Technical > Medical > Basic Sciences > Biotechnology
4Books > Subjects > Professional & Technical > Professional Science > Biological Sciences > Biotechnology
5Books > Subjects > Science > Biological Sciences > Biotechnology
6Books > Subjects > Science > General
7Books > Subjects > Science > Technology > General & Reference



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