Newsletter   Secure Checkout   View Cart (0 items)  
Search:    Welcome Guest! Save up to 30-40% on most items with our awesome everyday discounts!
Uveal Melanoma: A Model for Exploring Fundamental Cancer Biology [Hardcover]

Uveal Melanoma: A Model for Exploring Fundamental Cancer Biology [Hardcover]

By M J Jager (Author)
Our Price $ 85.40  
Retail Value $ 122.00  
You Save $ 36.60  (30%)  
Item Number 192436  
Buy New $85.40
Out Of Stock!
Currently Out Of Stock
Currently unavailable...

Item description for Uveal Melanoma: A Model for Exploring Fundamental Cancer Biology by M J Jager...

Uveal melanoma is the most common intraocular malignancy in adults and is characterized by aggressive metastases, which mainly develop hematogeneously. Little is known about the factors that predispose patients to develop this disease, although some factors such as skin pigmentation and the presence of multiple cutaneous nevi have been associated with an increased risk to develop uveal melanoma. The intraocular location of uveal melanoma offers excellent opportunities for visualization, and clinical study. While smaller tumors can be treated with eye-preserving therapies, larger tumors sometimes require enucleation of the eye. Since uveal melanomas are typically homogeneous, in contrast other malignancies, comparisons can be made between genetic, immunologic and histological tests on the same tumor. Many countries have excellent registries regarding the survival data of uveal melanoma patients. This has led to a series of studies correlating patient survival to various tumor parameters, such as chromosomal abnormalities, oncogene expression, and immunohistological parameters. The availability of several uveal melanoma cell lines has fostered novel in vitro and in vivo studies that have added to our knowledge about the immunology, genetics, and molecular biology of uveal melanoma. Among other findings, such studies have revealed that that uveal melanoma and cutaneous melanoma are remarkably different diseases. This book provides insights into some of these differences and summarizes recent developments regarding the basic research on biology and metastasis of uveal melanoma.

Promise Angels is dedicated to bringing you great books at great prices. Whether you read for entertainment, to learn, or for literacy - you will find what you want at!

Item Specifications...

Studio: Informa Healthcare
Pages   259
Est. Packaging Dimensions:   Length: 9.45" Width: 6.69" Height: 0.71"
Weight:   1.5 lbs.
Binding  Hardcover
Release Date   Jun 1, 2004
Publisher   Informa Healthcare
ISBN  9026519621  
ISBN13  9789026519628  

Availability  0 units.

More About M J Jager

Register your artisan biography and upload your photo! M. J. Jager has an academic affiliation as follows - Leiden University Medical School, The Netherlands.

Are You The Artisan or Author behind this product?
Improve our customers experience by registering for an Artisan Biography Center Homepage.

Product Categories

1Books > Subjects > Health, Mind & Body > Disorders & Diseases > Cancer > Skin Cancer
2Books > Subjects > Medicine > General
3Books > Subjects > Medicine > Internal Medicine > Oncology > General
4Books > Subjects > Medicine > Internal Medicine > Oncology
5Books > Subjects > Medicine > Specialties > Ophthalmology
6Books > Subjects > Professional & Technical > Medical > Medicine > Internal Medicine > Oncology
7Books > Subjects > Professional & Technical > Medical > Medicine > Surgery > Ophthalmology
8Books > Subjects > Science > Biological Sciences

Reviews - What do customers think about Uveal Melanoma: A Model for Exploring Fundamental Cancer Biology?

Biology of a Cure?  Jun 18, 2008
Why do some small and unremarkable primary uveal melanomas metastasize while larger, more invasive eye tumors do not?

What factors cause an existing choroidal nevus to transform into a choroidal melanoma? And how are those factors different from or similar to the ones that cause uveal melanomas to arise de novo (new)?

How on earth is it possible that the rates of incidence (the number of people diagnosed) and mortality (number of people dying) for uveal melanoma remain eerily unchanged for decades despite diagnosing and treatment advances?

Just what is uveal melanoma? More importantly, how do we successfully treat this rare and puzzling cancer?

This book does not answer any of these questions. So far, much of the research on uveal melanoma chromosomes, molecules and proteins has only confirmed long-standing clinical observations that tumor pigmentation, diameter, blood vessel morphology, cell type, race, and eye color influences its prevalence, progression and prognosis.

In other words, all this cellular research has merely affirmed on a genetic level what was already known on a clinical level.

Real progress will only be achieved when this genetic research is translated into improved patient outcomes - progress which appears decades away from reality.

If, as one of the authors argues, that uveal melanoma is "an excellent model for the study of cancer biology in general," than a more multi-disciplinary and-faceted approach is warranted. That kind of support is not only going to come from the lab but also from the larger community of medical professionals and their patients.

This was a fascinating book which ironically proves that research alone will not lead us to see a cure.

Write your own review about Uveal Melanoma: A Model for Exploring Fundamental Cancer Biology

Ask A Question or Provide Feedback regarding Uveal Melanoma: A Model for Exploring Fundamental Cancer Biology

Item Feedback and Product Questions
For immediate assistance call 888.395.0572 during the hours of 10am thru 8pm EST Monday thru Friday and a customer care representative will be happy to help you!

Help us continuously improve our service by reporting your feedback or questions below:

I have a question regarding this product
The information above is incorrect or conflicting
The page has misspellings or incorrect grammar
The page did not load correctly in my browser or created an error.

Email Address:
Anti Spam Question. To combat spammers we require that you answer a simple question.
What color is the sky?
Leave This Blank :
Do Not Change This Text :

Add This Product Widget To Your Website

Looking to add this information to your own website? Then use our Product Widget to allow you to display product information in a frame that is 120 pixels wide by 240 pixels high.

    Copy and paste the following HTML into your website and enjoy!

Order toll-free weekdays 10am thru 10pm EST by phone: 1-888-395-0572 (Lines are closed on holidays & weekends.)
Customer Service | My Account | Track My Orders | Return Policy | Request Free Catalog | Email Newsletter

Gift Certificates
RSS Feeds
About Us
Contact Us
Terms Of Use
Privacy Policy