Item description for The Practical Bioinformatician by Limsoon Wong...
Computer scientists have increasingly been enlisted as "bioinformaticians" to assist molecular biologists in their research. This book is a practical introduction to bioinformatics for these computer scientists. The chapters are in-depth discussions by expert bioinformaticians on both general techniques and specific approaches to a range of selected bioinformatics problems. The book is organized into clusters of chapters on the following topics:
Overview of modern molecular biology and a broad spectrum of techniques from computer science data mining, machine learning, mathematical modeling, sequence alignment, data integration, workflow development, etc. In-depth discussion of computational recognition of functional and regulatory sites in DNA sequences. Incisive discussion of computational prediction of secondary structure of RNA sequences. Overview of computational prediction of protein cellular localization, and selected discussions of inference of protein function. Overview of methods for discovering proteinprotein interactions. Detailed discussion of approaches to gene expression analysis for the diagnosis of diseases, the treatment of diseases, and the understanding of gene functions. Case studies on analysis of phylogenies, functional annotation of proteins, construction of purpose-built integrated biological databases, and development of workflows underlying the large-scale-effort gene discovery.
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Studio: World Scientific Publishing Company
Est. Packaging Dimensions: Length: 1" Width: 6" Height: 9" Weight: 2.05 lbs.
Publisher World Scientific Publishing Company
ISBN 981238846X ISBN13 9789812388469
Reviews - What do customers think about The Practical Bioinformatician?
More like "Practicing Bioinformatician" Jan 25, 2005
This is a survey book, with invited chapters covering a variety of subjects. This goes way beyond the basics. For example, it doesn't address BLAST internals or usage, but does describe how it can be used as one step in more complex computations.
The good parts are quite good. The first chapter's biology review is quick but generally adequate, except for a few over-simplifications like "the disease genes for ... breast cancer ... have been identified." They have? ALL of them, or just a few of the more important ones? The "Strategy and Planning" chapter is very weak, perhaps because it addresses such a huge and varied range of topics. Chapters on neural nets, motif finding, homology search (post-BLAST), probe design, and RNA structure are good, and have enough detail for a programmer to get started on. The data mining section has some good material, but doesn't really cover the full breadth of data mining (a book-length topic in itself). Other chapters, esp. phylogeny and database issues, don't rise to the same level.
The problems: Well, no index for one. There's a huge aggregate list of references (I would have preferred chapter by chapter), and even pictures of all the authors in the back, but no index. The table of contents is quite detailed, but hardly a replacement. Also, despite editorial policies meant to ensure uniformity between chapters, some inexplicable differences showed up. Sometimes it's a "translation start site (TSS)", other times a "translation initiation site (TIS)." The editing could have been a little tighter too. Criterion should be the singular of criteria, strata should be the plural of stratum, a few other annoyances should have been addressed as well. Editing should cover the illustrations, too. The diagram on p.411 has "mosquitoes" from poor compression, and the line drawings of ch.11 don't always connect connected lines. And of course this shows the usual problem of such books - it's an idiosyncratic selection of topics, giving erratic coverage to the field. If it hits your area of interest, great, but it may miss.
What's good here is quite good. It covers topics well into the post-genome age, using genome data rather than just trying to discover it. Still, the book as a whole is spotty - considering the price, I hoped for better. Also, readers expecting "Practical" to mean "Basic" are in for an unhappy surprise. You'd better have a very solid background before you pick this up.