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Cytokines and Pain (Progress in Inflammation Research) [Hardcover]

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Item description for Cytokines and Pain (Progress in Inflammation Research) by L.R. Watkins...

Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.

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Item Specifications...

Pages   244
Est. Packaging Dimensions:   Length: 9.2" Width: 6.4" Height: 0.8"
Weight:   1.5 lbs.
Binding  Hardcover
Release Date   Dec 7, 1998
Publisher   Birkhäuser Basel
ISBN  3764358491  
ISBN13  9783764358495  

Availability  109 units.
Availability accurate as of Oct 26, 2016 05:26.
Usually ships within one to two business days from La Vergne, TN.
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Product Categories

1Books > Subjects > Medicine > Basic Science > Immunology
2Books > Subjects > Medicine > Diseases > General
3Books > Subjects > Medicine > General
4Books > Subjects > Medicine > Internal Medicine > Neurology > General
5Books > Subjects > Medicine > Pharmacology > Pain Medicine
6Books > Subjects > Professional & Technical > Medical > Basic Sciences > Immunology
7Books > Subjects > Professional & Technical > Medical > Medicine > Internal Medicine > Neurology > General
8Books > Subjects > Professional & Technical > Medical > Pharmacology > Pain Medicine

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