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Genetic Entropy & the Mystery of the Genome [Paperback]

By John C. Sanford (Author)
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Item description for Genetic Entropy & the Mystery of the Genome by John C. Sanford...

In this text, Sanford, a retired Cornell professor, shows that the "Primary Axiom"--the foundational evolutionary premise that life is merely the result of mutations and natural selection--is false. He strongly refutes the Darwinian concept that man is just the result of a random and pointless natural process.

Publishers Description
Genetic Entropy presents compelling scientific evidence that the genomes of all living creatures are slowly degenerating due to the accumulation of slightly harmful mutations. This is happening in spite of natural selection. The author of this book, Dr. John Sanford, is a Cornell University geneticist. Dr. Sanford has devoted more than 10 years of his life to the study of this specific problem. Arguably, he has examined this problem in greater depth than any other scientist. The evidences that he presents are diverse and compelling. He begins by examining how random mutation and natural selection actually operate, and shows that simple logic demands that genomes must degenerate. He then makes a historical examination of the relevant field (population genetics), and shows that the best scientists in that field have consistently acknowledged many of the fundamental problems he has uncovered (but they have failed to communicate these problems to the broader scientific community). He then shows, in collaboration with a team of other scientists, that state-of-the-art numerical simulation experiments consistently confirm the problem of genetic degeneration (even given very strong selection and optimal conditions). Lastly, in collaboration with other scientists, he shows that real biological populations clearly manifest genetic degeneration. Dr. Sanford s findings have enormous implications. His work largely invalidates classic neo-Darwinian theory. The mutation/selection process by itself is not capable of creating the new biological information that is required for creating new life forms. Dr. Sanford shows that not only is mutation/selection incapable of creating our genomes it can t even preserve our genomes. As biochemist Dr. Michael Behe of Lehigh University writes in his review of Genetic Entropy, ...not only does Darwinism not have answers for how information got into the genome, it doesn't even have answers for how it could remain there. Dr. Sanford has coined the term genetic entropy to describe this fatal flaw of neo-Darwinian theory. This fundamental problem has been something of a trade-secret within the field of population genetics, with the rest of the world largely being kept in the dark. Fortunately, this book finally discloses this very serious problem, using language that is for the most part accessible to all scholars and students having a basic understanding of biology. This new edition of Genetic Entropy includes numerous new lines of evidence supporting Dr. Sanford s thesis. Much of this new evidence is from recently published scientific papers that are now part of the scientific literature. Genetic Entropy is a must-read for any thoughtful person who in interested in science. Dr. Sanford ends his book by asking two questions. First, if our genome did not actually arise via the accumulation of genetic word-processing errors (as is claimed), how did it arise? Second, if our genomes are undergoing relentless degeneration where can we possibly place our hope for the future?

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Item Specifications...

Studio: Feed My Sheep Foundation, Inc.
Pages   233
Est. Packaging Dimensions:   Length: 9.1" Width: 6.1" Height: 0.6"
Weight:   0.8 lbs.
Binding  Softcover
Release Date   Nov 7, 2014
Publisher   Feed My Sheep Foundation, Inc.
ISBN  0981631606  
ISBN13  9780981631608  

Availability  135 units.
Availability accurate as of Oct 20, 2016 05:29.
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Reviews - What do customers think about Genetic Entropy & the Mystery of the Genome?

Compelling  Jun 2, 2010
Dr. Sanford refutes the Primary Axiom of Darwinian evolution: that evolution is the result of natural selection acting upon random mutations. His approach is to create layer upon layer of specific "showstoppers" to this axiom, each of which compounds the showstopping aspects of the other layers. The whole book is full of technical insights that only someone who has an intimate knowledge of the field of genetics and genetic engineering could have. I was particularly impressed with the chapter on the mutation rate of the human genome (specifically with the numerous specific mechanisms of mutation he gives which guarantee that the genome must LOSE information, not gain it via evolution), as well as with the argument that genetic polyfunctionality makes it utterly impossible to gain information through random mutations even if all other arguments were disregarded (that is, many or most genes simultaneously code for more than one function, hence a random mutation that happens to benefit one function is overwhelmingly likely to harm the other functions). Every medical school and biology student should read this book!
This guy is an 'expert' on genetics?  Apr 19, 2010
I must start out by saying that I have not read this book. However, I saw a creationist present the follwing quote from it the other day:

"Haldane calculated that it would take (on average) 300 generations (>6,000 yrs) to select a single new mutation to fixation, given what he considered a 'reasonable' mixture of recessive and dominant mutations. Selection at this rate is so slow that it is essentially the same as no selection at all. This problem has classically been called 'Haldane's dilemma'. At this rate of selection, once could only fix 1,000 beneficial nucleotide mutations within the whole genome in the tiem since we supposedly evolved from chimps (6 million yrs). This simple fact has been confirmed independently by Crow and Kimura(1970), and ReMine (1993, 2005). The nature of selection is such that selecting for one nucleotide redues our ability to select for other nucleotides (selection interference). Simultaneous selection does not help.

"At first glance, the above calculation seems to suggest that one might at least be able to select for the creation of one small gene (of up to 1,000 nucleotides) in the time since we reputedly diverged from champanzee. There are two reasons why this is not true. 1. Haldane's calculation were only for independent, unlinked mutations. Selection for 1,000 specific and adjacent muations could not happen in 6 million yrs because that specific sequence of adjacent mutations would never arise, not even in 6 billion yrs."
-pp 128-9

Now, I will ignore for the moment that this Cornell 'geneticist' cites creationist electical engineer Walter ReMine for anything having to do with genetics, but if this quote is accurate, then Sanford either does not understand Haldane's model - AT ALL - or he is purposefully misrepresenting it to make his silly position seem more viable.

And apparently he isn't willing to talk about it - I emailed him more than 2 weeks ago, only asking if the quote was accurate. No reply.

Can anyone here verify the acuracy of that quote?
The beginning of a comprehensive understanding of genetics and if evolution fits in.  Apr 2, 2010
This book is a great read.

It helps you understand the fundamental level of where evolution should occur, in the genome.

Dr. John Sanford writes a very scientifically based book on how the mechanism of evolution can't work. Random mutations with natural selection CANNOT create complexity or design. Essentially mutations lose or distort information rather than creating it, even with natural selection only choosing "good mutations" which as you find out in this book are statistically negligible once you account for occurrence (one out of a million mutations is anything above the line of neutrality and a mutation occurs in only one out of a million replications), selection, genetic drift, mutational baggage, secondary effects, and further selection and the need of high selective pressure for the "new" attribute.

He gives some mild rebuttals to Richard Dawkin's the Blind Watchmaker examples.

I LOVED the book and would recommend it to anyone.
Neo-Darwinism - the final nail in the coffin!  Mar 9, 2010
I admit I already had serious doubts about neo-Darwinsim due to the silence in the fossil record, Cambrian Explosion, evidence of the Great Flood, the Biblical Account of Creation, and especially the teleology, Anthropic Principles, and evidence of purpose and design throughout the universe and especially in biology. In addition, the advancement of Intelligent Design, Information Theory, Irreducible Complexity, and all the rest of it gave me tremendous confidence in my beliefs. Then, as I read about the stunning complexity of the cell, DNA, and biological systems at the molecular level, my confidence grew even stronger. Then however, I come across Dr. Sanford's work on genetic entropy that has managed to Blow Me Away and take me to new levels I thought were unimaginable. Yes, he is a Christian, but his work is strictly scientific and well supported with peer reviewed articles as is his highly respected credentials. He boldy presents a formal proof that the "Primary Axiom" is wrong! Where else will you see that? Basically, the genome was perfect in the beginning but now is mutating and deteriorating and always has been. There is not even one single clear-cut case of a genetic mutation generating new, novel information - so how can Darwinian random mutation plus natural selection even work? In addition, with selection occuring at the phenome level and mutation occuring at the genome level, the whole mess doesn't even make sense even if it were to occur! Darwin couldn't have know this of course, not having access to the genetic code or even the cell's details for that matter. Look, whatever that intelligence is or was, designed all life as it is fixed today - that, this book will prove. This book is for everyone who asks the question: Who are we? Where did we come from? Where are we going? Excellent, superb book! This book could change your life!
Excellent insights for a layman  Nov 22, 2009
I really enjoyed reading Dr. Sanford's book, Genetic Entropy. Here are some words from it that I particularly appreciated: "the jump in complexity from a bacterium to a human being is arguably as great as the jump from the little red wagon to the space shuttle! There is simply no human technology that serves as an adequate analogy for the complexity of a human life."

Further on, he wrote these helpful words, which can make some sense to a layman: "These small molecules make up the individual steps of the spiral-staircase structure of DNA. These molecules are the letters of the genetic code, and are shown symbolically as A, T, C, and G. These letters are strung together like a linear text. They are not just symbolically shown as letters, they are very literally the letters of our instruction manual. Small clusters or motifs of these four molecular letters make up the words of our manual, which combine to form genes (the chapters of our manual), which combine to form chromosomes (the volumes of our manual), which combine to form the whole genome (the entire library)."

On pages 105f, Sanford wrote: "If the genome is actually degenerating, it is bad news for the long--term future of the human race. It is also bad news for evolutionary theory. If mutation/selection cannot preserve the information already within the genome, it is difficult to imagine how it could have created all that information in the first place!"

On page 135, he wrote: "a single gene is just a microscopic speck of irreducible complexity within the universe of irreducible complexity comprising a single cell. Life itself is the very essence of irreducible complexity, which is why we cannot even begin to think of creating life ourselves. Life is layer upon layer of irreducible complexity."

On page 150, he wrote: "If the Primary Axiom is wrong, then our basic understanding of life history is also wrong.... If the genome is degenerating, our species is not evolving. There appears to be a close parallel between the aging of a species and the aging of an individual. Both seem to involve the progressive accumulation of mutations. Mutations accumulate both within our reproductive cell lines and our body cell lines. Either way, the misspellings accumulate until a threshold is reached when things rapidly start to fall apart."

On page 154, he wrote: "What is the mystery of the genome? Its very existence is its mystery. Information and complexity which surpass human understanding are programmed into a space smaller than an invisible speck of dust. Mutation/selection cannot even begin to explain this. It should be very clear that our genome could not have arisen spontaneously. The only reasonable alternative to a spontaneous genome is a designed genome. Isn't that an awesome mystery-one worthy of our contemplation?"

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