Item description for Measuring Dynamic Network Interactions that Control Pituitary Gene Expression by Ignacio Demarco...
The combinatorial interactions of the homeodomain protein Pit-1 with transcription factors such as C/EBPalpha and with coregulatory proteins control the development of anterior pituitary cells. These cells fail to develop in individuals with mutations affecting the Pit-1 gene, resulting in combined pituitary hormone deficiency. The present work describes biochemical, live-cell imaging and in vivo kinetics studies that provide new insight into the dynamic network interactions inside the pituitary-cell nucleus. The findings reported here support a model where proteins move independently within the nuclear compartment and stochastically associate at specific intranuclear sites as part of metastable complexes. The probability that these proteins assemble in a particular region of the cell nucleus is related to the dominant chromatin-binding activities of the different protein partners, supporting the view that the repositioning of transcription factors and coregulators represents an important mechanism for directing changes in cell-specific gene expression. These studies also suggest an important link between the mislocalization of transcriptional complexes and disease processes.
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Est. Packaging Dimensions: Length: 9.61" Width: 6.69" Height: 0.36" Weight: 0.61 lbs.
Release Date Feb 13, 2008
Publisher VDM Verlag Dr. Mueller e.K.
ISBN 3836462311 ISBN13 9783836462310
Availability 74 units. Availability accurate as of May 28, 2017 12:54.
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