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Measuring Dynamic Network Interactions that Control Pituitary Gene Expression [Paperback]

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Item description for Measuring Dynamic Network Interactions that Control Pituitary Gene Expression by Ignacio Demarco...

The combinatorial interactions of the homeodomain protein Pit-1 with transcription factors such as C/EBPalpha and with coregulatory proteins control the development of anterior pituitary cells. These cells fail to develop in individuals with mutations affecting the Pit-1 gene, resulting in combined pituitary hormone deficiency. The present work describes biochemical, live-cell imaging and in vivo kinetics studies that provide new insight into the dynamic network interactions inside the pituitary-cell nucleus. The findings reported here support a model where proteins move independently within the nuclear compartment and stochastically associate at specific intranuclear sites as part of metastable complexes. The probability that these proteins assemble in a particular region of the cell nucleus is related to the dominant chromatin-binding activities of the different protein partners, supporting the view that the repositioning of transcription factors and coregulators represents an important mechanism for directing changes in cell-specific gene expression. These studies also suggest an important link between the mislocalization of transcriptional complexes and disease processes.

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Item Specifications...

Pages   168
Est. Packaging Dimensions:   Length: 9.61" Width: 6.69" Height: 0.36"
Weight:   0.61 lbs.
Binding  Softcover
Release Date   Feb 13, 2008
Publisher   VDM Verlag Dr. Mueller e.K.
ISBN  3836462311  
ISBN13  9783836462310  

Availability  74 units.
Availability accurate as of Oct 23, 2016 06:10.
Usually ships within one to two business days from La Vergne, TN.
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Product Categories

1Books > Subjects > Professional & Technical > Professional Science > Biological Sciences > Biology > Microbiology
2Books > Subjects > Science > Biological Sciences > Biology > Microbiology
3Books > Subjects > Science > General

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