Item description for Systems Biology in Practice: Concepts, Implementation and Application by Edda Klipp...
Presenting the main concepts, this book leads students as well as advanced researchers from different disciplines to an understanding of current ideas in the complex field of comprehensive experimental investigation of biological objects, analysis of data, development of models, simulation, and hypothesis generation.
It provides readers with guidance on how a specific complex biological question may be tackled:
How to formulate questions that can be answered
Which experiments to perform
Where to find information in databases and on the Internet
What kinds of models are appropriate
How to use simulation tools
What can be learned from the comparison of experimental data and modeling results
How to make testable predictions
The authors demonstrate how mathematical concepts can illuminate the principles underlying biology at a genetic, molecular, cellular and even organism level, and how to use mathematical tools for analysis and prediction.
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Est. Packaging Dimensions: Length: 9.5" Width: 6.8" Height: 1.1" Weight: 2.3 lbs.
Release Date May 6, 2005
ISBN 3527310789 ISBN13 9783527310784
Availability 0 units.
More About Edda Klipp
Edda Klipp (born 1965) studied biophysics at the Humboldt University Berlin, receiving her PhD in theoretical biophysics. Since 2001 she has been head of the Kinetic Modeling Group. A member of the Yeast Systems Biology Network, her research interests include mathematical modeling of cellular systems, signal transduction, systems biology, and text mining.
Ralf Herwig (born 1967) studied mathematics and physics at the TU Berlin and Free University Berlin and wrote his PhD on statistical clustering methods. He has been a group leader in bioinformatics since 2001 and works on several projects covering genomics, proteomics and systems biology.
Axel Kowald (born 1963) holds a PhD in mathematical biology from the National Institute for Medical Research, London. He has worked at the University of Manchester, the Institute for Advanced Studies in Budapest, and the Humboldt University Berlin. His current research interests focus on the mathematical modeling of processes involved in the biology of aging and systems biology.
Christoph Wierling (born 1973) studied biology at the University of Mer, graduating in 1999. Currently he is working as a PhD student on the modeling and simulation of biological systems and the development of computational tools for systems biology.
Hans Lehrach (born 1946) studied chemistry in Vienna and Braunschweig, receiving his PhD from the Max Planck Institute for Experimental Medicine. He is director of the MPI for Molecular Genetics and was spokesman for the German Human Genome. Among others, he is a member of EMBO, on the project committee of the National Genome Research Network, and a fellow of the American Association for theAdvancement of Science. His research interests focus on functional genomics, technology development and systems biology. All the authors currently work at the Max Planck Institute for Molecular Genetics in Berlin.
Edda Klipp has an academic affiliation as follows - MPI for Molecular Genetics, Berlin, Germany.
Reviews - What do customers think about Systems Biology in Practice: Concepts, Implementation and Application?
A nice book that covers a lot Mar 15, 2006
I'm studying biophysics and I recently bought the book "Systems Biology in Practice". It is quite expensive, but I wanted to read up about Systems Biology, since we currently discuss this in our Bioinformatics lectures.
The book consists of three major parts, the first contains three introductory chapters about biology, mathematics and experimental techniques, the second is the main part which contains 8 chapters that describe mathematical models of many different biological processes like gene expression, biological oscillations or signal transduction pathways. The last part has two chapters that deal with databases and software tools that are available over the internet.
I personally found the "Biology in a Nutshell" chapter very helpful, since my biological knowledge had several gaps and the chapter is a very condensed presentation of the most important biological facts. I think it is also the main aim of the three chapters about biology, mathematics and experimental techniques to provide people coming from different fields with some basic information about those topics.
All in all the book covers a large variety of different topics and the models and information is presented with helpful examples and figures, so that I find it quite entertaining to read.
My only point of critique is that I'm still not sure what systems biology is, since there seems to be no generally accepted definition. However, I found the book very useful to understand mathematical modelling of biochemical systems and I use it often as reference book.
I can not recommend this book! Jan 23, 2006
I thought a while before I started to write this review about how many points I should give. Does it realy deserve zero points? In my opinion, yes! (the rating system does not allow zero points)
I bought this very expensive book, written by five authors, and had so far no fun reading it nor does it provide valuable insights about currently the hot topic in biology. Let me just give some examples to make my point clear. First, not all chapters are written equal good/bad but differ. This implies that the five authors separated the chapters under each other. Chapter 4, "Experimental Techniques in a Nutshell" represents probably the negative highlight of the book. The author who has wirtten this chapter refuses persistenly to come to the point. I have to admit that it is almost impossible to explain mass spectromety, RNAi or DNA chips comprehensible if one has only one page for each of these topis. But is this not clear beforehand? This is a general problem of the book. It covers a huge list of differnt topics but the explanations of each topic is only shallow. Further examples for this: Baysian Networks, one page. Multiple linear regression, one page. Cell Cycle, one page. Ok, now we found a general law according to this the book was written. Compile a list of buzz words, order them in a meaningful way, and wirte one page to each of those terms. Finally, lets call it "Systems Biolog" and we are done. I don't think so, that's not it!
The only people this book could be useful for are undergraduate students who know nothing at all about this subject and want to get an overview about the topics collected under the phrase systems biology. But even for this reason one can not really recommend this book because it is far too expensive.
A final remark. It is clear, that books above the 100$ threshold deserve to be evaluated stronger because it hurts too buy them. If this book would cost 20$ I would give one point.