Item description for Selectins (Advances in Vascular Biology) by Dietmar Vestweber...
The selectins are the most recently discovered, and the smallest family of cell adhesion molecules. They not only mediate lymphocyte homing but their binding reaction also forms the first step in the entry of leukocytes to inflamed tissues. The inflammatory response is crucial in the host's defence against infectious micro-organisms, but can go drastically wrong, damaging host tissues in an acute reaction. Carbohydrate based selectin antagonists, as well as anti-selectin antibodies have been successfully used to combat this reaction in various animal models. Summarizing the present knowledge about the molecular mechanisms of selectin mediated cell adhesion, this volume forms an indispensable review of an important area of research. Its in depth handling of the consequences of this research for various physiological and patho-physiological processes will also be vital to the clinician specialising in inflammatory disorders.
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Studio: Harwood Academic Publishers
Est. Packaging Dimensions: Length: 9.96" Width: 6.72" Height: 0.88" Weight: 1.49 lbs.
Release Date Mar 19, 1997
Publisher Harwood Academic Publishers
ISBN 9057020742 ISBN13 9789057020742