Item description for The Lac Operon: A Short History of a Genetic Paradigm by Benno Muller-Hill...
This book describes the history and present knowledge of a paradigmatic system, the lac operon of E. coli. The first part of the book presents the history of the operon and various schools of thought regarding genetic control in general. The second part presents a number of false interpretations and misconceptions and demonstrates how easily a scientist may deceive himself. The third and last part thoroughly covers the current state of knowledge of the lac operon including the importance of the auxiliary operators and discussions of several X-ray structures, one of which was published shortly before this book went into press. A unique combination of personal anecdotes and present-day science makes this book appealing to students, postdocs, active and retired researchers alike.
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Est. Packaging Dimensions: Length: 9" Width: 6.1" Height: 0.4" Weight: 0.8 lbs.
Publisher Walter de Gruyter
ISBN 3110148307 ISBN13 9783110148305
Availability 86 units. Availability accurate as of May 29, 2017 05:47.
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Reviews - What do customers think about The Lac Operon: A Short History of a Genetic Paradigm?
A short review of a short history Dec 15, 2000
This book is like Ptashne's "Genetic switch" but more personal and at a higher scientific/intellectual level (read "Genetic Switch" first if you have no idea what it is). "The lac Operon" is annotated with many short, colourful, 'behind-the-scenes' anecdotes about the people who were (are) doing the science. These anecdotes, and other historical facts, do an outstanding job of placing the research questions of the time (the answers to which are today taken as 'self-evident truths') in context.
The lac Operon, a Paradigm of Beauty and Efficiency Jul 23, 1998
In "The lac Operon - A Short History of a Genetic Paradigm", Benno Mueller-Hill does an excellent job of describing the history, mistakes, and present-day view of the lac operon. I found it an enjoyable read. The book is written at a level that assumes the reader already knows a bit about molecular biology, and starts with "A Short History of the lac System from its Beginning to 1978". I found the middle section most interesting, where the mistaken interpretations of the lac operon are considered. This would be a very educational read for students (and post-docs and researchers) in the field. Finally, the last section discusses the current model for how the lac Operon works; this model has not made it to many of the undergraduate molecular biology / Genetics textbooks yet. Overall I was quite happy with this short book on the first bacterial operon to be characterised.