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Molecular Genetics of Recombination (Topics in Current Genetics) [Hardcover]

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Item description for Molecular Genetics of Recombination (Topics in Current Genetics) by Andrés Aguilera...

Genetic recombination is an important process involved in shaping the genetic make up of progeny. Increasingly, it has become evident that recombination is a DNA repair pathway crucial during DNA replication in vegetatively growing cells. It plays a critical role in preserving the integrity of the genome by mediating the repair of DNA damage, which can occur during normal cellular metabolism as a result of oxidative stress, transcription, replication fork stalling or breakdown, or after the exposure to DNA damaging agents. Until recently, much of our knowledge on the mechanisms of genetic recombination has come from studies of prokaryotic and simple eukaryotic fungal systems. However, these studies have now been significantly extended to mammals, such that a comparative picture of the general factors and mechanisms of genetic recombination is beginning to emerge. Detailed genetic and biochemical studies have led to the isolation and characterization of many of the recombination-repair proteins in E. coli and S. cerevisiae, which in turn has led to the identification of homologues in human cells. The link between recombination defects and recombination proteins in a number of tumors as well as in human hereditary syndromes makes genetic recombination a cellular process of key importance not only in basic biology but also in biomedical studies.





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Item Specifications...


Pages   524
Est. Packaging Dimensions:   Length: 9.29" Width: 6.3" Height: 1.34"
Weight:   2.16 lbs.
Binding  Hardcover
Release Date   May 3, 2007
Publisher   Springer
ISBN  3540710205  
ISBN13  9783540710202  


Availability  104 units.
Availability accurate as of Mar 28, 2017 07:47.
Usually ships within one to two business days from La Vergne, TN.
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Product Categories

1Books > Subjects > Professional & Technical > Professional Science > Biological Sciences > Biochemistry
2Books > Subjects > Professional & Technical > Professional Science > Biological Sciences > Biology > Cytology
3Books > Subjects > Professional & Technical > Professional Science > Biological Sciences > Biology > Microbiology
4Books > Subjects > Science > Biological Sciences > Biochemistry
5Books > Subjects > Science > Biological Sciences > Biology > Cell Biology
6Books > Subjects > Science > Biological Sciences > Biology > General
7Books > Subjects > Science > Biological Sciences > Biology > Microbiology
8Books > Subjects > Science > General



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