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Aromatase Inhibitors (Milestones in Drug Therapy) [Paperback]

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Item description for Aromatase Inhibitors (Milestones in Drug Therapy) by B. J. A. Furr, Marcelo Coniglio, Dov M. Gabbay, Paula Gouveia, Cristina Sernadas, Pat McEown, Glenn Barr & Kevin Nowlan...

Overview
Many breast tumours are dependent upon oestrogen for their development and continued growth. Hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action.

Publishers Description
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase).Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.

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Item Specifications...


Pages   189
Est. Packaging Dimensions:   Length: 0.75" Width: 6.5" Height: 9.25"
Weight:   1.1 lbs.
Binding  Softcover
Release Date   Feb 6, 2008
Publisher   Birkhäuser Basel
ISBN  3764386924  
ISBN13  9783764386924  


Availability  1 units.
Availability accurate as of Mar 29, 2017 05:09.
Usually ships within one to two business days from Momence, IL.
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More About B. J. A. Furr, Marcelo Coniglio, Dov M. Gabbay, Paula Gouveia, Cristina Sernadas, Pat McEown, Glenn Barr & Kevin Nowlan


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Product Categories

1Books > Subjects > Health, Mind & Body > Disorders & Diseases > Cancer > Breast Cancer
2Books > Subjects > Medicine > General
3Books > Subjects > Medicine > Internal Medicine > General
4Books > Subjects > Medicine > Internal Medicine > Oncology > General
5Books > Subjects > Medicine > Pharmacology > General
6Books > Subjects > Professional & Technical > Medical > Medicine > Internal Medicine > General
7Books > Subjects > Professional & Technical > Medical > Medicine > Internal Medicine > Oncology
8Books > Subjects > Professional & Technical > Medical > Pharmacology > Pharmacology



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